动脉粥样硬化(As),作为心脏病突发,中风和肢端坏疽的主要原因,在美国、欧洲和日本,它与全部死亡率中的半数疾病有关。As是由于动脉壁的内皮细胞和平滑肌细胞受各种危险因子的损伤,而使机体产生的一种过度的支性增生性反应过程。其中大量的生长因子、细胞因子和血管调节因子参与了此反应过程。因此我们可通过控制各种相关细胞中以上这些因子的基因表达,来寻找新的诊治As的药物,从而可以预防As的形成和使已经形成的As灶消退。 Atherosclerosis (As), a leading cause of heart attack, stroke and gangrenous gangrene, is associated with about half of all deaths in the United States, Europe and Japan. As is an overproduction of the proliferative response to the body due to the damage of endothelial cells and smooth muscle cells of the arterial wall by various risk factors. A large number of growth factors, cytokines and angiogenic factors involved in this reaction. Therefore, we can search for new drugs for the diagnosis and treatment of As by controlling the gene expression of these factors in various related cells, so as to prevent the formation of As and eliminate the already formed As spots.