论文部分内容阅读
目的探讨静脉丙种球蛋白(IVIG)对川崎病(KD)患儿血小板参数的影响及临床意义。方法将60例川崎病患儿随机分为IVIG组和对照组。测定治疗前、后血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)和血小板体积分布宽度(PDW)值的变化。结果治疗后2组PLT、PCT、MPV和PDW值均逐渐下降。但IVIG组MPV、PDW值变化更为显著,分别与对照组比较,差异均有统计学意义(P<0.01)。结论IVIG治疗川崎病(KD)的疗效明显优于传统方法;血小板的四项参数可作为判定川崎病评价疗效的参考指标之一,MPV变化与KD病情变化有关,联合检测有助于指导治疗和预后判定。
Objective To investigate the effect and clinical significance of intravenous gamma globulin (IVIG) on platelet parameters in children with Kawasaki disease (KD). Methods Sixty children with Kawasaki disease were randomly divided into IVIG group and control group. Changes of platelet count (PLT), platelet pressure (PCT), mean platelet volume (MPV) and platelet volume distribution width (PDW) before and after treatment were measured. Results After treatment, the PLT, PCT, MPV and PDW values decreased gradually in both groups. However, the changes of MPV and PDW in IVIG group were more significant, the difference was statistically significant (P <0.01) compared with the control group respectively. Conclusion The efficacy of IVIG in treatment of KD is obviously better than that of traditional methods. The four parameters of platelet can be used as a reference index to evaluate Kawasaki disease evaluation. The change of MPV is related to the change of KD. Prognosis.