目的:总结新生儿经皮中心静脉置管（percutaneous inserted central catheter, PICC）致静脉营养液渗漏的临床特点。方法:回顾性分析2015年1月至2019年12月北京大学第三医院新生儿重症监护病房诊断的16例PICC致静脉营养液渗漏新生儿的临床特点。采用描述性统计分析。结果:本院PICC致静脉营养液渗漏的发生率为1.6%（16/1 012）。16例PICC致静脉营养液渗漏患儿中13例胸腔渗漏，1例心包渗漏，2例脑脊液渗漏。16例均为早产儿，胎龄为（30.5±0.5）周，出生体重为（1 314.4±62.1）g。给予PICC的日龄为（4.3±0.6） d。从PICC置入到发生静脉营养液渗漏间隔时间为（7.3±2.0） d。13例胸腔渗漏患儿均表现为呼吸困难、呼吸暂停及皮肤发绀，1例心包渗漏患儿除有以上表现外还有心动过缓和血压下降，2例脑脊液渗漏患儿主要表现为嗜睡和惊厥。发生胸腔和心包渗漏的14例患儿PICC均从右贵要静脉置入，仅5例导管前端初始位置正确；4例初始置入过深，当天调整；发生静脉营养液渗漏时导管前端位置发生偏移10例。发生脑脊液渗漏的2例患儿PICC均从左大隐静脉置入，导管前端初始位置均不正确，但均未调整，发生静脉营养液渗漏时2例均发生置管前端偏移。16例患儿经穿刺抽液及拔除PICC后临床症状迅速缓解，未再反复。结论:PICC致静脉营养液渗漏可能与PICC置管前端向非中心静脉偏移有关。一旦诊断PICC致静脉营养液渗漏，应及时穿刺引流并拔除PICC，预后良好。“,”Objective:To summarize the clinical characteristics of intravenous nutrient solution leakage caused by percutaneous inserted central catheter (PICC) in newborns.Methods:This study retrospectively analyzed the clinical characteristics of 16 newborns with PICC-induced intravenous nutrient solution leakage in the neonatal intensive care unit of Peking University Third Hospital from January 2015 to December 2019. Descriptive statistical analysis was used.Results:The total incidence of intravenous nutrient solution leakage caused by PICC in our hospital was 1.6% (16/1 012). Thirteen cases had the nutrient solution leakage in the pleural cavity, one in the pericardium and two in the cerebrospinal fluid. All of the 16 cases were preterm infants with an average gestational age of (30.5±0.5) weeks and an average birth weight of (1 314.4±62.1) g. The average age at the time of PICC implantation was (4.3±0.6) d. The average interval between catheter insertion and intravenous nutrient solution leakage was (7.3±2.0) d. The 13 patients with nutrient solution leakage in the pleural cavity all showed dyspnea, apnea and cyanosis. Besides these manifestations, bradycardia and decreased blood pressure were also found in one patient with the leakage in the pericardium. The two cases with the leakage in the cerebrospinal fluid mainly showed drowsiness and convulsions. The catheters were all inserted from the right vena basilica in the 14 cases with leakage in the pleural cavity and pericardium. Only five of them had the correct initial position of the catheter tip, while too deep initial implantation was noted in four cases with later adjustment on the same day, and the shift of the catheter tip position was noted in 10 cases when the leakage-related symptoms occurred. The catheters were inserted from the left saphenous vein in the two cases with nutrient solution leakage in the cerebrospinal fluid, who had an incorrect initial position of the catheter tip, and the catheter tip position shifted in both cases when the leakage occurred. The leakage-related symptoms of all 16 cases were alleviated rapidly after puncture drainage and PICC extubation with no recurrence.Conclusions:PICC-induced leakage of intravenous nutrient solution may be related to the shift of the catheter tip to non-central veins. Once leakage is diagnosed, PICC should be removed as soon as possible and the prognosis is good after drainage.