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大鼠纹状体中多巴胺受体介导的C－fos基因的表达与多巴胺D1受体的超敏现象有关。本实验在鼠胚胎黑质细胞植入帕金森病大鼠模型纹状体后第12周，用免疫组化法检测阿朴吗啡诱发的C－fos蛋白,同时取相邻切片进行酷氨酸羟化酶检测，结果经图像分析发现胚胎黑质移植，能显著减少移植侧纹状体中C－fos的表达量，说明胚胎黑质移植能够纠正多巴胶受体的超敏现象。除此之外，还发现C－fos减少的区域明显超过相邻切片酷氨酸羟化酶免疫阳性区域，表明细胞移植对超敏的多巴胺受体的影响范围大大超过了其诱发宿主残存多巴胺神经元再生的范围。
Dopamine receptor-mediated C-fos gene expression in rat striatum correlates with the hypersensitivity of the dopamine D1 receptor. In this experiment, 12 weeks after the implantation of rat embryonic substantia nigra cells into the striatum of Parkinson’s disease rat model, apomorphine-induced C-fos protein was detected by immunohistochemistry and the adjacent sections were taken for the determination of tyrosine hydroxylase The results of enzyme-linked immunosorbent assay showed that embryonic substantia nigra transplantation could significantly reduce the expression of C-fos in the striatum on the transplanted side after image analysis, indicating that embryonic substantia nigra transplantation could correct the hypersensitivity of dopa glue receptor. In addition, it was found that the reduced area of C-fos significantly surpassed the adjacent section of the region homozygous for tyrosine hydroxylase, indicating that the effect of cell transplantation on hypersensitive dopamine receptors greatly exceeds that of the host-induced residual dopamine neurons Yuan regeneration range.