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目的探讨血清胆红素与糖尿病周围神经病变(DPN)的关系。方法收集110例2型糖尿病(T2DM)并发周围神经病变患者(DPN组)、220例单纯T2DM患者(DM组)和健康体检者278名(Con组)的血清胆红素等临床资料,并进行Logistic回归分析,筛选DPN的危险因素。对间接胆红素(IBIL)进行进一步的分析。结果 (1)低血清IBIL、病程长、LDL-C升高是DPN的危险因素。(2)协方差分析表明,控制尿白蛋白(UAlb)等因素后,DPN组的IBIL水平[(9.7±0.6)μmol/L]仍然明显低于DM组[(12.0±0.6)μmol/L]和Con组[(11.4±0.3)μmol/L]。结论低血清IBIL与DPN密切相关,是DPN发病相关因素之一。
Objective To investigate the relationship between serum bilirubin and diabetic peripheral neuropathy (DPN). Methods The clinical data of serum bilirubin in 110 T2DM patients with peripheral neuropathy (DPN group), 220 T2DM patients (DM group) and 278 healthy controls (Con group) Logistic regression analysis, screening of risk factors for DPN. Indirect bilirubin (IBIL) for further analysis. Results (1) low serum IBIL, long duration, elevated LDL-C is a risk factor for DPN. (2) The covariance analysis showed that the level of IBIL in DPN group was still significantly lower than that in DM group ([(9.7 ± 0.6) μmol / L [12.0 ± 0.6] μmol / L] after controlling UAb and other factors And Con group [(11.4 ± 0.3) μmol / L]. Conclusion Low serum IBIL is closely related to DPN and is one of the related factors of DPN.