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本文采用放免法测定31例老年心功能不全和20例健康老人的血浆钠素(ANP)浓度,发现老年心功能不全组明显低于对照组,分别为204.8 ±29.8pg/ml和359.5 ±42.8pg/ml(P<0.005)。心功能Ⅱ、Ⅱ和Ⅳ级血浆ANP分别为353.3±52.9pg/ml、214.4±64.5pg/ml和73.7±16.0pg/ml,三者之间差别有显著性(P<0.05)。心功能不全的病程与ANP浓度呈负相关(r=-0.441,P<0.02)。不同病因、不同受累部位及有无房颤之间差ANP差别无显著性(P>0.05)。本研究对老年心功能不全发病学的认识及寻找新的治疗方法和判断预后都有一定意义。
In this study, 31 cases of senile cardiac insufficiency and 20 healthy elderly plasma natriuretic peptide (ANP) concentrations were determined by radioimmunoassay and found that the elderly patients with cardiac dysfunction group was significantly lower than the control group 204.8 ± 29.8pg / ml and 359.5 ± 42.8pg / ml (P <0.005). The plasma levels of ANP in heart functions Ⅱ, Ⅱ and Ⅳ were 353.3 ± 52.9 pg / ml, 214.4 ± 64.5 pg / ml and 73.7 ± 16.0 pg / ml, respectively. There was a significant difference between the three groups (P <0.05). The duration of cardiac insufficiency was negatively correlated with ANP concentration (r = -0.441, P <0.02). There was no significant difference in ANP between different etiologies, affected sites and presence or absence of atrial fibrillation (P> 0.05). This study of senile heart failure pathogenesis awareness and find new treatments and prognosis are of some significance.