目的探讨老年慢性阻塞性肺疾病(COPD)患者疾病严重程度与动脉僵硬度的关系。方法选择年龄大于65岁的COPD患者153例,按照COPD全球倡议(GOLD)2011综合评估方法对患者进行病情评估并分组,症状少、低风险为A组,症状多、低风险为B组,症状少、高风险为C组,症状多、高风险为D组,同时根据年龄分为65~74岁组,75~84岁组,≥85岁组。以颈动脉-股动脉脉搏波传导速度(PWV)作为评价动脉僵硬度指标,分析不同组别COPD患者动脉僵硬度情况并分析相关因素。结果 D组年龄高于A组,D组患冠心病的比例高于A、B、C组(P<0.05);各组间性别、吸烟情况、患高血压、糖尿病、高脂血症的比例无统计学差异;所有患者中有84例(54.9%)动脉僵硬度增高;A、B、C、D组患者PWV均值比较有统计学差异(P<0.01);各组动脉僵硬度增高率A/B组、C/D组、A/C组、B/D组间比较,有统计学意义(P<0.05),而B/C组比较无统计学差异(P>0.05);在各年龄段中,D组患者PWV值及动脉僵硬度增高率高于A组患者(分别P<0.01及P<0.05);单因素分析结果显示,PWV>14 m/s与PWV≤14m/s的患者疾病严重程度、年龄、吸烟史、氧分压、收缩压及脉压存在差异;疾病严重程度、年龄、氧分压及脉压进入回归方程,COPD患者疾病严重程度是动脉僵硬度增高的独立影响因素。结论老年COPD合并动脉僵硬增高患者构成比高,动脉僵硬度随COPD疾病严重程度而增高,老年COPD患者疾病严重程度是动脉僵硬度增高的独立影响因素。 Objective To investigate the relationship between the severity of disease and arterial stiffness in elderly patients with chronic obstructive pulmonary disease (COPD). Methods A total of 153 COPD patients older than 65 years old were enrolled in the study. Patients were divided into groups according to the COPD Global Initiative (GOLD) 2011 comprehensive assessment method. The symptoms were low, the low risk was group A, the more symptoms were, the lower risk was group B, Less, high-risk group C, multiple symptoms, high-risk group D, at the same time according to age is divided into 65-74 years old group, 75-84 years old group, 85 years old group. Carotid artery - femoral artery pulse wave velocity (PWV) was used as an index to evaluate the arterial stiffness. The arterial stiffness of different groups of COPD patients was analyzed and related factors were analyzed. Results The age of group D was higher than that of group A, and the proportion of coronary heart disease in group D was higher than that of group A, B and C (P <0.05). The proportions of gender, smoking, hypertension, diabetes and hyperlipidemia There was no significant difference between the two groups (P> 0.05). There were 84 cases (54.9%) of all the patients with increased arterial stiffness. The mean of PWV in groups A, B, C and D was statistically significant / B group, C / D group, A / C group and B / D group (P <0.05), but no significant difference in B / C group In the segment, the increase rate of PWV and arterial stiffness in group D was higher than that in group A (P <0.01 and P <0.05, respectively). In univariate analysis, patients with PWV> 14 m / s and PWV <14 m / s The severity of disease, age, smoking history, partial pressure of oxygen, systolic pressure and pulse pressure were different. The severity of disease, age, partial pressure of oxygen and pulse pressure entered the regression equation. The severity of disease in COPD patients was independent of arterial stiffness factor. Conclusions The compositional ratio of COPD with arterial stiffness in elderly patients is high. Arterial stiffness increases with the severity of COPD. The severity of COPD patients is an independent factor of arterial stiffness.