阿司咪唑又名息斯敏,为组胺H_1-受体拮抗剂,可对抗内源性组胺,因不通过血脑屏障,故没有中枢镇静作用。阿司咪唑及其活性代谢产物去甲基阿司咪唑的清除半衰期分别为1～2d和9～13d,故具有长效作用。 也许是由于广告效应,有些人把阿司咪唑当成止痒药用,这是错误的。因为许多有痒感皮肤病如神经性皮炎、湿疹、牛皮癣等的发病机理与组胺无关,所以应用阿司咪唑往往无效。而急、慢性荨麻疹、季节性、过敏性皮炎等用阿司咪唑的疗效很好。还可用 Astemizole, also known as Westminster, is a histamine H 1 -receptor antagonist that is resistant to endogenous histamine because it does not cross the blood-brain barrier, so there is no central sedation. Asimirzole and its active metabolite to methyl esterase clearance half-life of 1 ~ 2d and 9 ~ 13d, it has long-term effect. Perhaps because of the advertising effect, some people use astemizole as itching medicinal, which is wrong. As many have itchy skin diseases such as neurodermatitis, eczema, psoriasis and other pathogenesis has nothing to do with histamine, so the application of astemizole often ineffective. And acute and chronic urticaria, seasonal, allergic dermatitis and other effects with astemizole very good. Also available