结肠癌肝转移依然是转移性疾病最普遍的形式。尽管局部化疗、放疗和免疫治疗可以使肿瘤暂时缓解 ,进展期结直肠癌病人的预后并没有改善。因此 ,结肠癌肝转移的处理迫切需要新的治疗方法 ,基因治疗即是候选者之一。在不同的肿瘤基因治疗策略中 ,埃希氏大肠杆菌胞嘧啶脱氨酶 (CD) Liver metastases from colon cancer remain the most common form of metastatic disease. Although local chemotherapy, radiotherapy and immunotherapy can temporarily relieve the tumor, the prognosis of patients with advanced colorectal cancer has not improved. Therefore, the treatment of liver metastases of colorectal cancer is urgently needed new treatment methods, gene therapy is one of the candidates. Among different strategies of tumor gene therapy, Escherichia coli CDase (CD)