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目的观察血必净对重症胸腹损伤患者急性凝血功能障碍和肝功能损伤的保护作用。方法将150例重症胸腹损伤患者随机分为观察组和对照组。所有患者入院后均立即抢救,积极抗休克、止血、改善微循环、保护胃肠黏膜及处理原发伤治疗。观察组在上述治疗基础上加用血必净注射液治疗。对比2组治疗前后血清凝血功能指标和肝功能指标变化。结果治疗前2组血小板计数(PLT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)和丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBil)、直接胆红素(DBil)水平差异无统计学意义(P>0.05)。治疗后2组PLT、TBil和DBil水平均升高,APTT和PT、ALT、AST水平均降低,且观察组波动幅度大于对照组,差异均有统计学意义(P<0.05)。结论血必净注射液可明显改善重症胸腹损伤患者凝血功能障碍,对患者肝功能损伤起到较好的保护作用,效果较明显,值得临床推广应用。
Objective To observe the protective effect of Xuebijing on acute coagulopathy and hepatic dysfunction in patients with severe thoracoabdominal injury. Methods 150 cases of severe chest and abdomen injury were randomly divided into observation group and control group. All patients were rescued immediately after admission, active anti-shock, hemostasis, improve microcirculation, protect the gastrointestinal mucosa and treatment of primary injury treatment. Observation group on the basis of the above treatment with Xuebijing injection treatment. The changes of serum coagulation and liver function before and after treatment were compared between two groups. Results Before treatment, PLT, APTT, PT and ALT, AST, total bilirubin (TBil), direct bilirubin (DBil) level difference was not statistically significant (P> 0.05). After treatment, the levels of PLT, TBil and DBil in both groups increased, the levels of APTT, PT, ALT and AST decreased, and the fluctuation range of the observation group was larger than that of the control group (P <0.05). Conclusion Xuebijing injection can significantly improve coagulation dysfunction in patients with severe thoracoabdominal injury, liver function in patients with a better protective effect, the effect is more obvious, it is worthy of clinical promotion and application.