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我们应用单克隆抗体(McAb)及免疫荧光技术,检测了33例慢性肾性肾功能不全患者(CRI)及27例健康人的外周血T淋巴细胞及其亚群。结果显示:CRI患者T淋巴细胞总数(OKT_3)、辅助性T细胞(OKT_4)较正常人显著下降(P<0.01),OKT_4/OKT_8比值亦较正常人显著下降(P<0.01)。说明CRI患者细胞免疫及其功能有损害。
We detected the peripheral blood T lymphocytes and their subsets in 33 patients with chronic renal insufficiency (CRI) and 27 healthy controls by using monoclonal antibodies (McAbs) and immunofluorescence techniques. The results showed that the total number of T lymphocytes (OKT 3) and OKT 4 in patients with CRI decreased significantly (P <0.01) and the ratio of OKT 4 / OKT 8 was significantly lower than that in normal people (P <0.01). CRI patients with cellular immunity and its function is impaired.