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有关前列腺素类的药物在眼科应用的研究较多。PGF2α的局部应用能明显地降低眼压,但其副作用明显。PGF2α-IE对青光眼和高眼压患者均有效,但也能引起明显的结膜充血,表面刺激作用较重,故不能应用于临床;PhXA34,能降低眼压,其副作用也较轻。PhXA34(13, 14-dihydro-15R,S-17-phenyl-18,19,20-trinor-PGF2α-isopropylester)是15R(PhXA41)和15S差位异构体的混合物,其中15R的生物活性较强,被命名为PhXA41(WHO将其命名为latanoprost,化学名为13,14-dihydro-17-phenyl-18,19,
Prostaglandin drugs in ophthalmic applications more research. Topical application of PGF2α can significantly reduce intraocular pressure, but its side effects are obvious. PGF2α-IE is effective in patients with glaucoma and ocular hypertension, but can also cause significant conjunctival hyperemia, the role of surface irritation heavier, it can not be applied to clinical; PhXA34, can reduce intraocular pressure, its side effects are also lighter. PhXA34 (13, 14-dihydro-15R, S-17-phenyl-18,19,20-trinor-PGF2a-isopropylester) is a mixture of 15R (PhXA41) and 15S epimer, with 15R being more bioactive , Named PhXA41 (WHO names it latanoprost, whose chemical name is 13,14-dihydro-17-phenyl-18,19,