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目的评价高压氧(HBO)治疗对成人支气管哮喘的临床疗效。方法支气管哮喘患者287冽,按住院时间顺序编号,单号为HBO组,有患者145例,在常规治疗的同时接受HBO治疗;双号为对照组,有患者142例,仅接受常规治疗,即吸入布地奈德干粉剂(BUD)治疗。结果在治疗第1周末,HBO组和对照组患者晨间呼气峰流速(PEFam)较基线值分别提高(19±4)L/min和(10±3)L/min(P<0.01),4周治疗结束后2组较基线值分别提高(39±7)L/min和(28±6)L/min(P<0.01);晚间呼气峰流速(PEFpm)的改变与PEFam相似;日间和夜间症状评分在2组治疗1周末比较差异均有统计学意义(P<0.05).4周治疗结束,HBO组下降的程度与对照组比较差异有统计学意义(P<0.05)。治疗期间2组患者肝、肾功能及血压、心率、心电图均无明显改变,但HBO组患者血压、心率均有下降的趋势,差异无统计学意义(P>0.05)。2组不良事件的发生率比较差异无统计学意义(P>0.05)。结论HBO治疗配合吸入糖皮质激素是控制哮喘的一项有效措施,优于单一糖皮质激素吸入治疗,2者可协同作用。
Objective To evaluate the clinical effect of hyperbaric oxygen therapy (HBO) on adult bronchial asthma. Methods A total of 287 支 patients with bronchial asthma were numbered according to the time of hospitalization. The single number was HBO group. 145 patients were treated with HBO while in routine treatment. The double number was control group. There were 142 patients with conventional therapy Inhaled budesonide dry powder (BUD) treatment. Results At the end of the first week of treatment, morning peak expiratory flow (PEFam) in HBO group and control group increased by (19 ± 4) L / min and (10 ± 3) L / min respectively compared with baseline (P <0.01) After 4 weeks of treatment, the changes of PEF in the two groups were similar to PEFam (39 ± 7) L / min and (28 ± 6) L / min respectively (P <0.01) (P0.05) .At the end of 4 weeks, the degree of descending in HBO group was significantly different from that in control group (P0.05) .Conclusion: 1. There was no significant change in liver and kidney function, blood pressure, heart rate and electrocardiogram in the two groups during the treatment period, but the blood pressure and heart rate of HBO group had a tendency of decline, with no significant difference (P> 0.05). There was no significant difference in the incidence of adverse events between the two groups (P> 0.05). Conclusion HBO treatment combined with inhaled corticosteroids is an effective measure to control asthma, which is better than single glucocorticoid inhalation therapy. The two can work synergistically.