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目的探讨HBV-DNA定量与α-L-岩藻糖苷酶(AFU)和甲胎蛋白(AFP)浓度变化的关系。方法对373例慢性乙型肝炎患者血清进行HBV-DNA定量、AFU与AFP浓度检测,根据HBV-DNA水平分为3组:HBV-DNA 1×103copies/ml以下为阴性组;HBV-DNA 1×104～1×105copies/ml为低病毒量组;HBV-DNA 1×106～1×108copies/ml为高病毒量组进行分析。结果不同病毒量组的AFU、AFP浓度变化显示HBV-DNA低病毒量组和高病毒量组与正常对照组比较的差异则有统计学意义(P<0.05)。AFU与AFP的阳性比例随病毒复制量的增加而升高。结论对乙型肝炎病毒感染者,应定期进行血清HBV-DNA定量检测,评估病毒的复制状况,并同时检测AFU和AFP浓度,尽早发现肝组织的损害程度及演变过程,达到早期治疗的目的 。
Objective To investigate the relationship between HBV DNA quantification and α-L-fucosidase (AFU) and α-fetoprotein (AFP) concentrations. Methods Serum HBV-DNA, AFU and AFP concentrations were measured in 373 patients with chronic hepatitis B, and were divided into three groups according to HBV-DNA levels: HBV-DNA 1 × 103copies / ml or less; HBV-DNA 1 × 104 ~ 1 × 105copies / ml for the low-virus group; HBV-DNA 1 × 106-1 × 108copies / ml for the high-virus group for analysis. Results The changes of AFU and AFP concentrations in different viral load groups showed that the difference between HBV-DNA low viral load group and high viral load group and normal control group was statistically significant (P <0.05). The positive ratio of AFU to AFP increased with the increase of virus replication. Conclusions For patients with hepatitis B virus infection, serum HBV-DNA should be detected quantitatively to assess the replication status of the virus. At the same time, the concentrations of AFU and AFP in serum should be detected, and the extent of damage and evolution of liver tissue should be detected as early as possible to achieve the purpose of early treatment.