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研究了用心肌胶原含量定量测量晚期灶状心肌坏死程度的方法。给大鼠皮下注射异丙肾上腺素(ISP)和饮含丙烯胺的水造成灶状心肌坏死。测定心室肌羟脯氨酸含量并计算出胶原含量。用逐区点测量法定量测量心肌纤维化程度。结果发现注射ISP后和饮丙烯胺水21天的动物心肌胶原含量与其心肌纤维化程度呈明显正相关。本研究结果表明,心肌胶原含量可定量测量晚期灶状心肌坏死程度。
A method for quantitatively measuring the degree of late focal myocardial necrosis with collagen collagen content was studied. Subcutaneous injection of isoproterenol (ISP) and drinking water containing acrylamide caused focal myocardial necrosis. The hydroxyproline content of the ventricular muscle was measured and the collagen content was calculated. The measurement of myocardial fibrosis was quantitatively measured by a zone-by-zone measurement. The results showed that there was a positive correlation between the content of myocardial collagen and the degree of myocardial fibrosis in animals injected with ISP and drinking acrylamide water for 21 days. The results of this study indicate that myocardial collagen content can be used to quantitatively measure the degree of late focal myocardial necrosis.