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1972年到1982年间初治的急性早幼粒细胞白血病57例,其中男性29例,女性28例,平均年龄41岁。1977年以前33例为Ⅰ组,77年以后24例为Ⅱ组。诱导方案为柔红霉素100mg/M~2/日×3天,阿糖胞苷连续静脉滴注100mg/M~2/日×5天,缓解后维持治疗3年。支持疗法包括:(1)住单人病房、无菌饮食和肠道灭菌,从化疗第五天起到粒细胞恢复期间给予预防性的粒细胞输注(1×10~(10)细胞/M~2/日)若有感染给予治疗性粒细胞输注(2×10~(10)细胞1M~2/日),发热病人给予预防性抗生素。(2)在化疗同时进行预防DIC的治疗。全部病人的中数生存期为3.5个月,CR53％,中数缓解期为11个月。两组之间CR率无显著差异。患者无发热(P<0.05)和白细胞低于15,000/mm~3(P<0.05)较易获得CR,年龄小于30岁患者的CR率
There were 57 cases of acute promyelocytic leukemia treated from 1972 to 1982, including 29 males and 28 females, with an average age of 41 years. Before the year 1977, 33 cases were group I, and after 77 years, 24 cases were group II. The induction program was daunorubicin 100 mg/M~2/day x 3 days. The cytarabine was continuously infused with 100 mg/M~2/day*5 days. After the remission, it was maintained for 3 years. Supportive therapies include: (1) Living in a single ward, sterile diet, and intestinal sterilisation. Prophylactic granulocyte infusion (1 x 10 to 10 cells/cell) during the granulocytic recovery from the fifth day of chemotherapy M 2 /day) If the infection is given to the therapeutic granulocyte infusion (2×10 10 cells 1M to 2 days), fever patients will receive prophylactic antibiotics. (2) The prevention of DIC is performed concurrently with chemotherapy. The median survival time of all patients was 3.5 months, CR53%, and the median remission period was 11 months. There was no significant difference in CR rates between the two groups. Patients with no fever (P<0.05) and white blood cells below 15,000/mm~3 (P<0.05) were more likely to get CR, and CR rates were less than 30 years old