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1989年10月到1990年4月,我们采用细针顺铂注射治疗(PCI)3例肝癌,收到一定疗效.例1男,42岁.B 超、CT 示肝内肿块,直径18.4×14.7cm,细针穿刺活检,病理诊断:肝细胞型肝癌。采用 PCI 一次后,B 超复查,肿块大小无变化,胎甲球值(AFP)从795.89ng/ml 降至400ng/ml,肝胆酸值(CG)从1523.64μg/dl 降至986.98μg/dl.患者要求改用其它方法治疗,出院后,随访4个月死亡.例2,男,51岁.B 超,CT 示肝内肿块,直径5.9×4.0cm,细针穿刺活检,病理诊断:肝细胞型肝癌.PCI4次后,AFP 由535ng/ml 降至245.9ng/ml,肝癌特异性蛋白质(SHC SP)由阳性转为阴性,CG 从1584.8μg/dl 降至947.4μg/dl,唾液酸(F-8836)治疗前后均在正常值范围,B 超复查肿块缩小为3.8×2.2cm,细针穿刺活检,病理示癌细胞变性坏死.随访,已存活10个月。例3,女,56岁,结肠癌术后一年,B 超示肝内肿块直径14.2×10.2cm,穿刺活检,病理诊断:肝转移腺癌。PCI5次后,AFP 治疗前后均在正常值范围,SHCsP 转为阴性.CG 从117.5μg/dl降至76.6μg/dl,F-8836从0.230A 降至0.195A,
From October 1989 to April 1990, we used fine-needle cisplatin injection (PCI) in 3 cases of liver cancer and received certain curative effects. Example 1 Male, 42 years old. B-ultrasonography, CT showed intrahepatic mass, diameter 18.4×14.7 Cm, fine-needle aspiration biopsy, pathological diagnosis: hepatocellular carcinoma. After a single use of PCI, B-ultrasound showed no change in the size of the tumor. The AFP decreased from 795.89 ng/ml to 400 ng/ml. Hepatobiliary acid (CG) decreased from 1523.64 μg/dl to 986.98 μg/dl. The patient was asked to switch to other methods of treatment. After discharge, the patient was followed up for 4 months. Example 2, male, 51 years old. B ultrasound, CT showed intrahepatic mass, diameter 5.9×4.0 cm, fine needle aspiration biopsy, pathological diagnosis: hepatocytes After 4 times of PCI, the AFP was reduced from 535ng/ml to 245.9ng/ml, the specificity of liver cancer-specific protein (SHC SP) changed from positive to negative, CG decreased from 1584.8μg/dl to 947.4μg/dl, and sialic acid (F). -8836) before and after treatment in the normal range, B-repeated tumors were reduced to 3.8 × 2.2cm, fine-needle aspiration biopsy, pathology showed degeneration and necrosis of cancer cells. Follow-up, has survived for 10 months. Example 3, female, 56 years old, One year after colon cancer operation, B ultrasound showed that the diameter of intrahepatic mass was 14.2×10.2 cm, biopsy, pathological diagnosis: liver metastatic adenocarcinoma. After PCI 5 times, AFP was in the normal range before and after treatment, and SHCsP became negative. CG decreased from 117.5μg/dl to 76.6μg/dl and F-8836 decreased from 0.230A to 0.195A.