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目的:为分析脑卒中的危险因素及其与血管紧张素转换酶插入/缺失(ACEI/D)多态性的关系。方法:用PCR方法分析117例脑缺血、19例脑出血ACEI/D多态性和100例原发性高血压患者。用SASS分析软件分析脑卒中的危险因素。结果:DD基因型频率和D等位基因频率比较:脑卒中组显著高于正常对照组;有脑卒中家族史脑缺血患者显著高于无家族史者。高血压组与正常对照组相比,无显著差别。脑出血组的高血压的发生率显著高于脑缺血组,脑缺血组舒张压值显著高于脑出血组,两组高血压的发生率显著高于脑缺血组,脑缺血组舒张压值显著高于脑出血组,两组高血压发生率及血压值显著高于对照组,所有脑卒中患者的HDL-C均低于对照组。结论:Logistic逐步回归分析显示:DD基因型、脑卒中家族史。吸烟、左心室肥厚是脑卒中的独立危险因素。
Objective: To analyze the risk factors of stroke and its relationship with the angiotensin converting enzyme insertion / deletion (ACEI / D) polymorphism. Methods: 117 cases of cerebral ischemia, 19 cases of cerebral hemorrhage ACEI / D polymorphism and 100 cases of essential hypertension were analyzed by PCR method. SASS analysis software was used to analyze the risk factors for stroke. Results: The frequencies of DD genotype and D allele were significantly higher in stroke group than those in normal control group. The incidence of stroke with family history of cerebral ischemia was significantly higher than that of no-family history. There was no significant difference between hypertensive group and normal control group. The incidence of hypertension in cerebral hemorrhage group was significantly higher than that in cerebral ischemia group. The diastolic blood pressure in cerebral ischemia group was significantly higher than that in cerebral hemorrhage group. The incidence of hypertension in both groups was significantly higher than that in cerebral ischemia group and cerebral ischemia group The diastolic blood pressure value was significantly higher than that of cerebral hemorrhage group. The incidence of hypertension and blood pressure in both groups were significantly higher than those in control group. HDL-C in all stroke patients was lower than that in control group. Conclusion: Logistic regression analysis shows that DD genotype and family history of stroke. Smoking, left ventricular hypertrophy is an independent risk factor for stroke.