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目的：探讨宫颈粘膜相关淋巴瘤（ＣＭＡＬＴ－ｏｍａ）及假性淋巴瘤（ＣＰＬ）的诊断标准、鉴别诊断及发病机理。方法：ＣＭＡＬＴ－ｏｍａ及ＣＰＬ各５例，活检或手术标本做石蜡切片及免疫组化（ＡＢＣ法）染色。结果：ＣＭＡＬＴ－ｏｍａ出现“淋巴上皮病变”及单克隆增殖，２例为Ｔ小多形细胞性，３例为Ｂ细胞性（ＣＣＬ和淋巴浆细胞型）。ＣＰＬ均有多克隆性的多种炎细胞浸润。结论：大多数ＭＡＬＴ－ｏｍａ为低度恶性并有“回归”现象。因此，手术为首选治疗方法。如果肿瘤侵犯邻近脏器或转移至淋巴结，应加用化疗或放疗。ＣＰＬ应予以有效的抗菌治疗，否则，有转变成ＭＡＬＴ－ｏｍａ的可能。自身免疫性疾病及感染，可导致机体产生获得性ＭＡＬＴ，并在持续性刺激下发展为ＣＰＬ，进而转变为ＣＭＡＬＴ－ｏｍａ。
Objective: To investigate the diagnostic criteria, differential diagnosis and pathogenesis of cervical mucosa-associated lymphoma (CMALT-oma) and pseudolymphoma (CPL). Methods: CMALT-oma and CPL in 5 cases, biopsy or surgical specimens paraffin sections and immunohistochemistry (ABC method) staining. RESULTS: CMALT-oma showed “lymphoid epithelial lesions” and monoclonal proliferation, two were T polymorphic and three were B cell (CCL and lymphoid plasma cell type). CPL polyclonal multiple inflammatory cell infiltration. Conclusions: Most MALT-oma are low-grade and have a “regression” phenomenon. Therefore, surgery is the preferred method of treatment. If the tumor invades the adjacent organs or metastases to lymph nodes, chemotherapy or radiotherapy should be added. CPL should be effective antimicrobial therapy, otherwise, the possibility of conversion to MALT-oma. Autoimmune diseases and infections can cause the body to produce acquired MALT and develop CPL with sustained stimulation, which translates into CMALT-oma.