本项工作的目的是研究长期滴用血管收缩剂引起豚鼠鼻粘膜的组织病理和组织化学的改变.取平均年龄为5至8月的豚鼠40只,35只为实验对象,5只为对照,以0.05%萘唑啉硝酸盐(鼻眼净)用特别细小的滴入器滴入实验动物鼻腔,一日三次.将实验动物分为7组,每组5只,分别在2、4、6、8、12和16周时杀死每组动物,在手术显微镜下解剖取下呼吸粘膜,并分成两份,第一部分用Bouin’s液固定,做石蜡切片用苏木精伊红染色,做组织病理检 The purpose of this work is to study the histopathological and histochemical changes of nasal mucosa in guinea pigs induced by long-term use of vasoconstrictor.Under the average age of 40 guinea pigs from May to August, 35 were experimental subjects and 5 as control, 0.05% naphthalone nitrate (nasal eye net) with a special small drop into the nasal cavity of experimental animals, three times a day.The experimental animals were divided into 7 groups of 5, respectively, in 2, 4, 6 Each group of animals was sacrificed at weeks 8, 12 and 16, and the respiratory mucosa was dissected under the surgical microscope and divided into two sections. The first section was fixed with Bouin’s solution and paraffin sections were stained with hematoxylin and eosin for histopathology Check