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肿瘤的早期诊断依然是目前需要攻克的难关,现有的抗肿瘤药物因具有较大毒性和缺乏特异性而存在很大的局限性。纳米金能够被多种基团修饰从而获得对肿瘤细胞的靶向性,已成为当前抗肿瘤研究的热点。研究发现纳米金可以通过抑制血管生成、携带抗肿瘤药物以及光热效应等达到肿瘤治疗的目的,同时由于修饰后的纳米金对肿瘤细胞具有靶向性,在肿瘤的早期诊断方面也具有重要的意义。纳米金在体内的分布和代谢与其大小、形态及所带电荷有关,有关纳米金毒性和生物相容性性的评价,还有待于进一步研究。
The early diagnosis of neoplasm is still the current need to overcome the difficulties, the existing antitumor drugs due to greater toxicity and lack of specificity and there is a big limitation. Nano-gold can be modified by a variety of groups in order to obtain the targeting of tumor cells, which has become the current hot topic of anti-tumor research. The study found that nano-gold can inhibit tumor angiogenesis, anti-tumor drugs and photothermal effects to achieve the purpose of cancer treatment, at the same time as the modified nano-gold has targeted tumor cells in the early diagnosis of cancer is also of great significance . The distribution and metabolism of gold nanoparticles in vivo are related to their size, morphology and charge. The evaluation of the toxicity and biocompatibility of gold nanoparticles remains to be further studied.