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目的:探讨米非司酮配伍安定用于疤痕子宫中孕引产的有效性、安全性。方法:将孕14周～28周自愿要求终止妊娠的健康疤痕子宫孕妇96例,口服米非司酮75mg,12小时重复1次,共150mg,服用第一次米非司酮后即给利凡诺100mg羊膜腔内注射。有规律宫缩且宫口开大1～2cm时,给安定10mg缓慢静脉推注。结果:96例中在羊膜腔内注入利凡诺25小时分娩84例(87.5%),12例31小时内分娩(12.5%)。无宫颈裂伤、子宫破裂、阴道大出血及引产失败者。结论:米非司酮配伍安定用于疤痕子宫中孕引产缩短流产时间,软化宫颈,减少软产道损伤和病人痛苦具有良好的协同作用,安全有效。
Objective: To investigate the efficacy and safety of mifepristone in combination with diazepam in the treatment of induced abortion in uterine scar. Methods: Pregnant 14 weeks to 28 weeks of voluntary termination of pregnancy healthy pregnancy uterus 96 cases of pregnant women, oral mifepristone 75mg, 12 hours repeated 1, a total of 150mg, after taking the first mifepristone to give Lee Fan Connaught 100mg amniotic cavity injection. Regular contractions and open the cervix 1 ~ 2cm, to a stable 10mg bolus intravenous injection. Results: Ninety-eight (87.5%) cases of levofavir were delivered in amniotic cavity within 25 hours and 12 cases delivered within 31 hours (12.5%). No cervical laceration, uterine rupture, vaginal bleeding and induction of labor failure. Conclusion: The combination of mifepristone and diazepam for the treatment of short-term abortion in the uterine scar pregnancy has a good synergistic effect in softening the cervix, reducing the damage of soft birth canal and the patient’s pain, and is safe and effective.