[目的 ]探讨亚慢性苯中毒敏感的早期生物监测指标。 [方法 ]将小白鼠按不同染毒浓度和时间进行静式吸入染毒。 2 0d后 ,对其外周血WBC计数及超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT) ,谷胱甘肽过氧化物酶 (GSH Px)及白细胞吞噬发光指标进行检测。 [结果 ]在苯中毒早期WBC正常范围时 ,SOD、GSH Px及白细胞吞噬发光已发生变化 ,为进一步研究苯中毒早期诊断指标提供了依据。 [结论 ]SOD、GSH Px活力和白细胞吞噬发光的变化比白细胞计数更加敏感。 [Objective] To investigate the early biological monitoring indicators sensitive to sub-chronic benzene poisoning. [Method] The mice were inhaled by static inhalation at different exposure concentration and time. After 20 days, the peripheral blood WBC count, SOD, CAT, GSH Px and leukocyte phagocytosis were detected. [Results] The SOD, GSH Px and leukocyte phagocytosis had changed in the early WBC normal range of benzene poisoning, which provided a basis for further study on the early diagnosis of benzene poisoning. [Conclusion] The changes of SOD, GSH Px activity and leukocyte phagocytosis are more sensitive than leukocyte counts.