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目的：探讨睡前服雷尼替丁控制夜间胃酸是否是治疗胃溃疡的重要疗法。方法：活动性良性胃溃疡１５１例，随机分２组。雷尼替丁组７８例（男性４２例，女性３６；年龄５２±ｓ１０ａ），睡前服雷尼替丁胶囊３００ｍｇ，ｑｄ×１２ｗｋ。安慰剂组７３例（男性４０例，女性３３例；年龄５２±９ａ），睡前服安慰剂胶囊，ｑｄ×１２ｗｋ。结果：经治疗６和１２ｗｋ后溃疡愈合率，雷尼替丁组分别为７６％和９１％，安慰剂组分别为３８％和７０％，２组疗效比较经Ｘ２检验Ｐ＜０．０１。无不良反应。结论：睡前服雷尼替丁３００ｍｇ是治疗胃溃疡的好方法。
Objective: To investigate whether nocturnal administration of ranitidine before bedtime is an important therapy for gastric ulcer. Methods: 151 cases of active benign gastric ulcer were randomly divided into two groups. Ranitidine group of 78 patients (42 males, 36 females; age 52 ± s10a), ranitidine capsules before bedtime 300mg, qd × 12wk. The placebo group of 73 patients (40 males, 33 females; age 52 ± 9a), placebo capsules before bedtime, qd × 12wk. Results: The healing rates of ulcer after 6 and 12 weeks of treatment were 76% and 91% in ranitidine group and 38% and 70% in placebo group, respectively. The curative effect of two groups was compared with that of χ2 test (P <0.01). No adverse reactions. Conclusions: Ranitidine 300 mg at bedtime is a good treatment for gastric ulcer.