Though the quantum spin Hall effect (QSHE) in two-dimensional (2D) crystals has been widely explored,the experimental realization of quantum transport properties is only limited to HgTe/CdTe or InAs/GaSb quantum wells.Here we employ a tight-binding model on the basis of dz2,dxy,and dx2-y2 orbitals to propose QSHE in the triangular lattice,which are driven by a crossing of electronic bands at the Γ point.Remarkably,2D oxidized Mxenes W2M2C3 are ideal materials with nontrivial gap of 0.12 eV,facilitating room-temperature observations in experiments.We also find that the nontrivially topological properties of these materials are sensitive to the cooperative effect of the electron correlation and spin-orbit coupling.Due to the feasible exfoliation from its 3D MAX phase,our work paves a new direction towards realizing QSHE with low dissipation.