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目的:研究C-反应蛋白(CRP)和肿瘤坏死因子α(TNF-α)水平与中青年急性脑梗死的关系。方法:选择中青年急性脑梗死85例为观察组,随机分为常规治疗亚组42例和阿托伐他汀治疗亚组43例;常规治疗亚组采用常规方法治疗,阿托伐他汀治疗亚组在常规治疗的基础上,加阿托伐他汀20mg/d治疗。选择健康体检35例为对照组。观察比较各组治疗前、治疗后14天、30天血清CRP和TNF-α水平,以及治疗前、治疗后30天神经功能缺损(NIHSS)评分。结果:治疗前观察组血清CRP、TNF-α水平均非常显著高于对照组(P<0.01);治疗14天后,CRP、TNF-α水平均较治疗前非常显著降低(P<0.01);治疗30天后,CRP、TNF-α水平与对照组比较,差异不显著(P>0.05)。治疗30天后,两亚组血清CRP、TNF-α水平及NIHSS评分分值均非常显著低于治疗前(P<0.01);两亚组间比较,差异不显著(P>0.05)。急性脑梗死复发者治疗前CRP、TNF-α水平非常显著高于非复发者(P<0.01)。结论:血清CRP和TNF-α水平与中青年脑梗死关系密切。
Objective: To investigate the relationship between C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and acute cerebral infarction in middle-aged and young adults. Methods: A total of 85 middle-aged and young patients with acute cerebral infarction were selected as the observation group and were randomly divided into conventional treatment subgroup (n = 42) and atorvastatin treatment subgroup (n = 43). Conventional treatment subgroups were treated by conventional method and atorvastatin subgroup On the basis of routine treatment, add atorvastatin 20mg / d treatment. Select 35 cases of healthy physical examination as control group. The levels of CRP and TNF-α in serum before treatment, 14 days and 30 days after treatment were observed and compared. The scores of NIHSS before treatment and 30 days after treatment were compared. Results: Before treatment, serum levels of CRP and TNF-α in the observation group were significantly higher than those in the control group (P <0.01). After 14 days of treatment, CRP and TNF-α levels were significantly lower than those before treatment (P <0.01) After 30 days, the levels of CRP and TNF-α were not significantly different from those of the control group (P> 0.05). After 30 days of treatment, the levels of CRP, TNF-α and NIHSS in both sub-groups were significantly lower than those before treatment (P <0.01). There was no significant difference between two sub-groups (P> 0.05). The levels of CRP and TNF-α in relapsed patients with acute cerebral infarction were significantly higher than those without recurrence (P <0.01). Conclusion: Serum levels of CRP and TNF-α are closely related to young and middle-aged cerebral infarction.