论文部分内容阅读
目的 评价瑞格列奈、二甲双胍联合治疗 2型糖尿病的疗效。方法 4 4例初发 2型糖尿病病人服用瑞格列奈及二甲双胍 ,疗程 12周 ,监测治疗前后体重指数 (BMI)、空腹及餐后 2h血糖 (FBG、PBG)、糖基化血红蛋白 (HbAlc)、空腹胰岛素水平。结果 FBG、PBG及HbAlc较治疗前显著下降 (P <0 0 0 1) ,BMI较治疗前下降 ,胰岛素抵抗指数较前下降 (P <0 0 0 1) ,肝、肾功能无变化 ,无严重低血糖发生。结论 瑞格列奈联合二甲双胍治疗 2型糖尿病具有降糖作用 ,改善胰岛素敏感性及减轻体重指数 ,安全性、耐受性良好的特点。
Objective To evaluate the efficacy of repaglinide and metformin in the treatment of type 2 diabetes mellitus. Methods Forty-four patients with newly diagnosed type 2 diabetes were treated with repaglinide and metformin for 12 weeks. Body mass index (BMI), fasting and postprandial 2-hour blood glucose (FBG), glycosylated hemoglobin (HbAlc) , Fasting insulin levels. Results FBG, PBG and HbAlc were significantly lower than those before treatment (P <0.01), BMI was lower than before treatment, insulin resistance index was lower than before (P <0.01), liver and kidney function did not change, no serious Hypoglycemia occurs. Conclusion Repaglinide combined with metformin in treatment of type 2 diabetes has hypoglycemic effect, improve insulin sensitivity and reduce body mass index, safety, well-tolerated characteristics.