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发热是儿童最常见的病症,临床常用的解热药大多配成复方制剂,也有部分单方制剂,其主要成分多为乙酰水杨酸(acetylsalicylic acid,ASA)、非那西汀、氨基比林、安乃近、对乙酰氨基酚(paracetamol,PCL)等,一般认为它们的不良反应大小的排序为:非那西汀、氨基比林、安乃近、ASA、PCL.1 常用的对人体产生不良反应的解热药1.1苯胺类的非那西汀及PCL 儿童应用此类药可引起血液系统及肝、肾损害.新生儿和婴幼儿对非那西汀特别敏感,易致高铁血红蛋白症,非那西汀在体内吸收后主要代谢产物为PCL,还有一部分生成氨基苯乙醚,其进一步代谢的产物可氧化血红蛋白,使变成高铁血红蛋白,使至失去带氧能力,造成组织缺氧、溶血并损害肝脏,还可引起血尿和蛋白尿等肾
Fever is the most common illness in children. Most commonly used antipyretics are usually formulated in combination with some unilateral preparations. The main components are mostly acetylsalicylic acid (ASA), phenacetin, aminopyrine, Metamizole, acetaminophen (paracetamol, PCL), etc., generally considered the order of their adverse reaction size: phenacetin, aminopyrine, metamizol, ASA, PCL.1 commonly used in human adverse reactions The antipyretics 1.1 aniline phenacetin and PCL children application of these drugs can cause blood system and liver and kidney damage.Neonatal and infant sensitive to phenacetin is particularly susceptible to methemoglobinemia, The main metabolites of naloximene in the body after absorption is PCL, and a part of aminoethene ether is formed, and its further metabolized product can oxidize hemoglobin so that it becomes methemoglobin so as to lose oxygen-carrying capacity and cause tissue hypoxia and hemolysis Damage to the liver, but also cause hematuria and proteinuria and other kidneys