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[目的]提供实验用食蟹猴的正常生理生化、免疫学、脑脊液指标的参考值。[方法]选取50只4～7岁食蟹猴,雌性24只,雄性26只,分别检测其生理学(心电图、体温、心率)、血液学(血常规、凝血酶原时间)、血液生化学、免疫学(CD3+、CD4+、CD8+、IgG、IgM)和脑脊液(白细胞、葡萄糖、蛋白质、氯化物)指标,并进行性别间比较。[结果]雌雄性动物相比,血常规指标中WBC差异有统计学意义(P﹤0.01);血生化指标中ALP、CHO、CRE、GLU差异有统计学意义(P﹤0.05);免疫学指标中IgM差异有统计学意义(P﹤0.01);脑脊液指标中蛋白质含量差异有统计学意义(P﹤0.05)。其余各检测指标差异无统计学意义(P﹥0.05)。[结论]本研究提供了食蟹猴生理生化、免疫学、脑脊液的背景数据,为其在生物医学领域的应用提供参考。
[Objective] To provide the reference value of normal physiological and biochemical, immunological and cerebrospinal fluid indexes of experimental cynomolgus monkeys. [Methods] Fifty cynomolgus monkeys (aged 4 to 7 years old), 24 females and 26 males were enrolled in this study. Their physiology (electrocardiogram, body temperature and heart rate), hematology (blood routine, prothrombin time), blood biochemistry, Immunology (CD3 +, CD4 +, CD8 +, IgG, IgM) and cerebrospinal fluid (white blood cells, glucose, protein, chloride) indicators, and sex comparison. [Results] Compared with the male and female animals, there was a significant difference in WBC between the two groups (P <0.01). There were significant differences in ALP, CHO, CRE and GLU among the blood biochemical indexes (P <0.05) (P <0.01). There was significant difference in the content of protein in cerebrospinal fluid (P <0.05). There was no significant difference between the other indexes (P> 0.05). [Conclusion] This research provided the background data of physiology and biochemistry, immunology and cerebrospinal fluid in cynomolgus monkeys for reference in the field of biomedicine.