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目的:观察中西医结合治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHs)的疗效及探讨其可能的作用机制。方法:将120例OSAHS脾虚湿困、痰瘀阻窍证患者随机分为2组各60例,对照组采用综合疗法治疗,治疗组在对照组治疗的基础上加用化痰祛瘀开窍中药汤剂治疗。2组均以30天为1疗程,1疗程结束后比较2组的临床疗效,采用乔治医院呼吸问题调查问卷(SGRQ)评价生活质量,检测外周血清内皮素-1(ET-1)浓度的变化。结果:疗程结束后,对照组愈显率为65.0%,治疗组愈显率为88.3%,2组比较,差异有显著性意义(P<0.05)。2组SGRO评分、ET-1浓度均较治疗前有所降低(P<0.05),治疗组降低的趋势更为明显,与对照组比较,差异均有显著性意义(P<0.05)。ET-1浓度与SGRQ评分呈负相关。结论:中西医结合治疗OSAHS疗效确切,其作用机制可能与下调外周血清中ET-1的浓度相关。
Objective: To observe the curative effect of traditional Chinese and western medicine on obstructive sleep apnea-hypopnea syndrome (OSAHs) and to explore its possible mechanism. Methods: 120 cases of OSAHS patients with spleen dampness and phlegm stasis syndrome were randomly divided into two groups (n = 60 in each group). The control group was treated with combination therapy. The treatment group was treated with phlegm, blood stasis and resuscitation Agent treatment. The patients in both groups were treated for 30 days for one course of treatment. After one course of treatment, the clinical efficacy of the two groups was compared. The quality of life was assessed using the SGRQ questionnaire. The changes of endothelin-1 (ET-1) . Results: After the treatment, the cure rate of the control group was 65.0%, and the cure rate of the treatment group was 88.3%. There was significant difference between the two groups (P <0.05). SGRO score and ET-1 concentration in both groups were lower than those before treatment (P <0.05), and the decreasing trend in the treatment group was more obvious. Compared with the control group, the difference was significant (P <0.05). ET-1 concentration and SGRQ score was negatively correlated. Conclusion: Integrative treatment of OSAHS is effective and its mechanism may be related to the decrease of serum ET-1 concentration.