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Ｎ Ｆ－ κ Ｂ是参与基因转录的蛋白质分子，广泛存在于机体各种组织细胞中。当细胞受到外界因素刺激时，胞质内 Ｎ Ｆ－ κ Ｂ 与抑制蛋白（ Ｉκ Ｂｓ） 分离并活化，进入细胞核内与 Ｄ Ｎ Ａ 结合启动基因转录，调节包括细胞因子和炎症介质（ 如 Ｉ Ｌ－ ２ 、 Ｉ Ｌ－ ２ａ、 Ｉ Ｌ－ ６ 、 Ｉ Ｌ－ ８ ， Ｖ Ｃ Ａ Ｍ、 Ｉ Ｃ Ａ Ｍ、 Ｅ－ｓｅｌｅｃｔｉｎ 、 Ｉ Ｆ Ｎ－ β、 Ｍ Ｃ Ｐ－ １ 、 Ｒ Ａ Ｎ Ｔ Ｅ Ｓ等） 在内的众多蛋白质表达，从而参与调节组织细胞的生理、病理反应。在抑制 Ｎ Ｆ－ κ Ｂ 活化的药物， Ｎ Ｆ－ κ Ｂ、细胞因子与肾脏疾病关系方面研究也有一定的进展。
N F - κ B is involved in gene transcription of protein molecules, widely found in various tissues of the body cells. When the cells are stimulated by external factors, the cytoplasmic N F-κ B is separated from the inhibitory protein (Iκ Bs) and activated into the nucleus to bind with D N A to initiate transcription of the gene, including cytokines and inflammatory mediators (such as IL - 2, I L- 2a, I L- 6, I L- 8, VCA M, I C A M, E-selectin, I F N- β, M C P- 1, R A N T E S Etc.), many proteins involved in the regulation of the physiological and pathological response of tissue cells. In the inhibition of NF-κB activation of drugs, NF-κB, cytokines and kidney disease research has some progress.