近年来,对多种肿瘤组织和正常组织的对比研究发现,染色体脆性位点抑癌基因的减少和缺失与肿瘤的发生密切相关,其具体的作用机制尚待进一步研究明确。但其对肿瘤生物学行为的影响具有一定的临床应用价值。笔者就染色体脆性位点抑癌基因的结构和功能,可能的作用机制以及与肿瘤的发生、发展的相关研究进展进行综述,并对未来的研究前景进行展望。 In recent years, a variety of tumor tissues and normal tissue contrast study found that chromosomal fragile locus reduction and deletion of tumor suppressor genes are closely related to the occurrence of the tumor, the specific mechanism remains to be further studied. But its impact on tumor biological behavior has some clinical value. The author summarizes the structure and function of the tumor suppressor gene of chromosomal fragile locus, possible mechanism of action and related research progress with tumor occurrence and development, and prospects the future research prospects.