目的:研究胎盘中趋化因子SDF-1/CXCR4表达与妊娠期高血压疾病及新生儿出生体重之间的关系。方法:以10例妊娠期高血压患者为高血压组,10例轻度子痫前期患者为轻度子痫前期组,12例重度子痫前期患者为重度子痫前期组,35例正常产妇为对照组,以采用免疫组织化学法检测胎盘中SDF-1/CXCR4的表达强度,记录新生儿出生体重。结果:随着妊娠期高血压疾病病情加重,胎盘中SDF-1/CXCR4表达强度呈渐进性下降趋势,均低于对照组。对照组胎盘中SDF-1/CXCR4的表达与新生儿出生体重无统计学相关性。妊娠期高血压疾病患者胎盘中SDF-1、CXCR4的表达与新生儿出生体重有显著相关性。结论:胎盘中SDF-1、CXCR4表达强度变化与妊娠期高血压疾病发病及新生儿出生体重有重要关系。 AIM: To investigate the relationship between placental expression of chemokine SDF-1 / CXCR4 and gestational hypertension and newborn birth weight. Methods: 10 hypertensive patients with gestational hypertension were included, 10 mild preeclampsia patients were mild preeclampsia group, 12 severe preeclampsia patients were severe preeclampsia group and 35 normal pregnant women were In the control group, the expression intensity of SDF-1 / CXCR4 in the placenta was detected by immunohistochemistry and the birth weight of the newborn was recorded. Results: With the aggravation of hypertensive disorders in pregnancy, the expression intensity of SDF-1 / CXCR4 in placenta decreased gradually, which were all lower than those in control group. There was no significant correlation between the expression of SDF-1 / CXCR4 in the control group and the birth weight of newborns. There was a significant correlation between the expression of SDF-1 and CXCR4 in the placenta and the birth weight of neonates with gestational hypertension. Conclusion: The changes of the expression of SDF-1 and CXCR4 in placenta are closely related to the incidence of gestational hypertension and birth weight.