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日本脑炎(JBE)病理学的研究,在1935年前多着重于神经系统,以后明了内脏病理变化的存在,从而引起人们重视阐明感染途径的研究。作者报导日本脑炎病毒经口引起和感染。实验用中山株病毒,感染动物为重100克左右的田鼠,另以7—8克重小白鼠作测定病毒量。病毒量分别为10~(9.2),108~(8.9),107~(7.9),106~(6.9)LD_(50).用导尿管作口胃接种,后每3天取实验动物各脏器测定病毒量及观察病理变化。实验结果表明:(1)服10~(9.2)LD_(50)组动物,于接种后6—8天全部发病死亡;10~(8.9)LD_(50)组动物于7—11天也
Japanese encephalitis (JBE) pathology research, more emphasis on the nervous system in 1935, and later clear the existence of visceral pathological changes, which led to people pay attention to elucidate the route of infection. The authors report that the Japanese encephalitis virus is orally induced and infected. Experiment with Zhongshan strain of virus, infected animals weighing about 100 grams of voles, and the other with 7-8 grams of mice for the determination of viral load. The viral load was 10 ~ (9.2), 108 ~ (8.9), 107 ~ (7.9), 106 ~ (6.9) LD_ (50) The virus was measured and pathological changes were observed. The results showed that: (1) All the animals in the 10 ~ (9.2) LD_ (50) group died within 6-8 days after inoculation, and the animals in the 10 ~ (8.9) LD_ (50)