肾性高血压早在黄帝内经太素的玉藏诊脉篇已有类似的记载,故Winier及Warkerlin认为中国医生是最早认识肾性高血压的。1827年Bright氏推测高血压与肾脏疾患有关。1898年Tigerstedt与Bermen用兔肾的盐水浸出液注入动物体内引起高血压,并将此种物质命名为肾素(Re-nin)。1934年Goldblatt作了阻断肾动脉血流诱发肾性高血压的动物实验,且可将肾素定量(1Goldblatt单位=0.42微克)。近年来,Ruyter及Oberling等用电子显微镜发现在肾小球的入球动脉邻近球囊30～50微米处的血管壁有一种上皮样细胞,称为邻 Renal hypertension as early as in the Yellow Emperor within the Su-element of the Tibetan medicine have similar records, so Winier and Warkerlin that Chinese doctors are the first to recognize renal hypertension. In 1827 Bright’s speculation about hypertension and kidney disease. In 1898, Tigerstedt and Bermen were injected into the animal’s body with a saline solution of rabbit kidney to cause hypertension and named the substance Re-nin. Goldblatt made an animal experiment blocking renal blood flow-induced renal hypertension in 1934 and renin quantification (1 Goldblatt unit = 0.42 micrograms). In recent years, Ruyter and Oberling and other electron microscopy found in the glomerular afferent artery near the balloon 30 to 50 microns in the vessel wall has an epithelial-like cells called adjacent