硫化氢(H2S)作为继NO和CO之后的第三类气体信号分子被人们所认知,被研究证实在人体的许多器官组织都有内源性H2S的产生,其对血管内皮的生理学效应也逐步得到认识。肿瘤坏死因子(TNF-α)是一种有效的肿瘤杀伤因子,在血管炎症与免疫应答中的作用十分重要。本文对H2S和TNF-α在血管内皮的不同作用以及二者共同的影响做一综述。 Hydrogen sulfide (H2S), as the third type of gas signaling molecule following NO and CO, is well known and has been demonstrated to produce endogenous H2S in many tissues of the body and its physiological effects on the vascular endothelium Gradually recognized. Tumor necrosis factor (TNF-α) is a potent tumor-killing factor that plays an important role in vascular inflammation and immune response. This article summarizes the different roles of H2S and TNF-α in the vascular endothelium and their combined effects.