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目的 :观察四氢叶酸钙 (CF)、五氟脲嘧啶 (5 -FU)及羟基喜树碱 (HCPT)治疗不能手术切除的大肠癌疗效。方法 :6 6例经过手术探查或经影像学检查证实不能行根治手术的大肠癌患者分成两组对比研究 ,治疗组 36例以CF、 5 -FU与HCPT组成的联合化疗方案治疗 ;对照组以CF +5 -FU方案治疗。结果 :两组均无CR病例 ,治疗组PR16例 ,NC14例 ,PD6例 ,有效率 4 4 4 % ;对照组PR6例 ,NC14例 ,PD10例 ,有效率 2 0 0 % ,两组有效率差异有显著性。两组毒副反应主要为骨髓抑制和胃肠道反应 ,多为Ⅰ～Ⅱ度毒副反应。结论 :CF +5 -FU +HCPT治疗大肠癌疗效较高、副作用小 ,是治疗晚期大肠癌值得推荐的化疗方案
Objective: To observe the curative effect of unresectable colorectal cancer treated with calcium tetrafluorofolate (CF), pentafluorouracil (5 -FU) and hydroxycamptothecin (HCPT). Methods: Sixty-six patients with colorectal cancer who had undergone surgical exploration or confirmed by imaging examination were not divided into two groups. Patients in the treatment group were treated with CF, 5-FU and HCPT. The control group CF +5 -FU program treatment. Results: There were no CR cases in both groups. PR 16 cases, 14 cases of NC and 6 cases of PD, the effective rate was 44.4% in the treatment group; PR6 cases, NC14 cases and PD10 cases in the control group, the effective rate was 200% Significant. The two groups of mainly side effects of bone marrow suppression and gastrointestinal reactions, mostly Ⅰ ~ Ⅱ degree of toxicity. Conclusion: The treatment of colorectal cancer with CF +5 -FU + HCPT has higher efficacy and less side effects, which is a recommended chemotherapy regimen for the treatment of advanced colorectal cancer