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目的探讨血清肿瘤标志物鳞状细胞癌抗原(SCC)、癌胚抗原(CEA)、糖链抗原125(CA125)、糖链抗原199(CA199)在宫颈癌诊断中临床应用价值。方法收集病理确诊的92例宫颈癌患者作为宫颈癌组,另选体检中心同期健康体检者80例为对照组,检测血清SCC、CEA、CA125、CA199浓度,并分析其与病理类型、临床分期的相关性。结果宫颈癌组患者血清SCC、CEA、CA125、CA199水平明显高于对照组,宫颈鳞癌组SCC的阳性率明显高于宫颈腺癌组,CEA、CA125、CA199阳性率明显低于宫颈腺癌组,临床Ⅲ/Ⅳ期宫颈癌患者肿瘤标志物阳性率明显高于Ⅰ/Ⅱ期,联合检测的敏感性显著高于单独检测,差异均有统计学意义(P<0.05)。结论 SCC-Ag、CEA、CA125、CA199联合检测可有效提高宫颈癌诊断的敏感性,对鉴别病理类型及临床分期具有一定的意义,值得临床推广应用。
Objective To investigate the clinical value of serum tumor markers SCC, CEA, CA125 and CA199 in the diagnosis of cervical cancer. Methods Totally 92 patients with cervical cancer who were pathologically diagnosed as cervical cancer group and 80 healthy subjects were selected as the control group at the same time. The serum concentrations of SCC, CEA, CA125 and CA199 were detected and compared with the pathological type, clinical stage Correlation. Results The positive rates of SCC, CEA, CA125 and CA199 in cervical cancer group were significantly higher than those in control group. The positive rate of SCC in cervical squamous cell carcinoma group was significantly higher than that in cervical adenocarcinoma group. The positive rates of CEA, CA125 and CA199 in cervical cancer group were significantly lower than those in cervical adenocarcinoma group The positive rate of tumor markers in patients with stage Ⅲ / Ⅳ cervical cancer was significantly higher than that in stage Ⅰ / Ⅱ, the sensitivity of combined detection was significantly higher than that of the single test, the difference was statistically significant (P <0.05). Conclusion The combined detection of SCC-Ag, CEA, CA125 and CA199 can effectively improve the sensitivity of cervical cancer diagnosis, which has certain significance for differentiating the pathological type and clinical stage, and worthy of clinical application.