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目的 :研究肝硬化患者血浆和腹水一氧化氮 (NO)、白细胞介素 - 6 (IL - 6 )及肿瘤坏死因子α(TNFα)的变化及其意义。方法 :用比色法、ELISA法分别测定 5 0例肝硬化患者血浆和腹水的NO、IL - 6及TNFα。结果 :肝硬化组血浆和腹水NO、IL- 6及TNFα水平均显著高于对照组 (P <0 0 1)。腹水渗出液中NO、IL - 6及TNFα水平明显高于漏出液 (P <0 0 1或 0 0 5 )。结论 :检测血浆和腹水中NO、IL - 6及TNFα有助于肝硬化腹水的鉴别诊断
Objective: To study the changes of nitric oxide (NO), interleukin - 6 (IL - 6) and tumor necrosis factor α (TNFα) in plasma and ascites of cirrhotic patients and its significance. Methods: The levels of NO, IL - 6 and TNFα in plasma and ascites of 50 cirrhotic patients were determined by colorimetric assay and ELISA respectively. Results: The levels of NO, IL-6 and TNFα in plasma and ascites of cirrhosis group were significantly higher than those in control group (P <0.01). The levels of NO, IL - 6 and TNFα in ascites exudates were significantly higher than those in the effusion (P <0.01 or 0.05). Conclusion: The detection of NO, IL - 6 and TNFα in plasma and ascites can be helpful in the differential diagnosis of ascites of cirrhosis