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观察了丁基苯酞（ＮＢＰ）对局部脑缺血大鼠记忆障碍的影响．用穿梭箱进行学习记忆获得性训练，以主动回避反应潜伏期和次数以及逃避反应潜伏期为指标，评价大脑中动脉阻断（ＭＣＡＯ）后记忆保持的能力．结果表明：假手术组的记忆功能与正常组没有显著差别，而缺血对照组大鼠主动回避反应次数减少６０％，主动回避和逃避反应潜伏期分别较缺血前延长４．２±１．６和４．１±３．３ｓ．给ＮＢＰ３０和１００ｍｇｋｇ－１后主动回避反应的次数明显提高，主动回避反应潜伏期明显缩短，与缺血对照组比较均有非常明显的差别．表明ＮＢＰ对局部脑缺血引起的记忆障碍有明显改善作用．
The effect of butylphthalide (NBP) on memory impairment in rats with focal cerebral ischemia was observed. Using shuttle box for learning and memory acquisition training, the ability of memory retention after middle cerebral artery occlusion (MCAO) was evaluated by taking the initiative to avoid the reaction latency and the number of times and the escape latency. The results showed that there was no significant difference in memory function between the sham operation group and the normal group, but the number of active avoidance reaction in the ischemic control group decreased by 60% and the latency of active avoidance and avoidance reaction prolonged by 4.2 ± 1.6 And 4.1 ± 3.3s. The number of active avoidance response to NBP30 and 100 mg kg-1 was significantly increased, and the latency of active avoidance response was significantly shortened, with significant differences compared with the ischemic control group. NBP shows a significant improvement in memory impairment caused by focal cerebral ischemia.