Granular cell tumor (GCT) is uncommon in the colon andrectum.Here we report a case of GCT in the transversecolon.A 48-year-old male patient underwent a screeningcolonoscopy.A yellowish sessile lesion,about 4 mm indiameter,was found in the transverse colon.An endoscopicsnare resection was performed without complication.Histological examination revealed the tumor consisted ofplump neoplastic cells with abundant granular eosinophiliccytoplasm containing acidophilic periodic acid Schiff-positive,diastase-resistant granules.Immunohistochemicalanalysis showed the tumor cells expressed S-100 proteinand neuron-specific enolase.Thus,the resected tumor wasdiagnosed as a GCT.Since GCTs are usually benign,endoscopicresection constitutes an easy and safe treatment.Colonoscopists should consider the possibility of GCT inthe differential diagnosis of submucosal tumors of the colon. A 48-year-old male underwent a screening colonoscopy. A yellowish sessile lesion, about 4 mm indiameter, was found in the transverse colon. End of endoscopicsnare resection was performed without complication. Histological examination revealed the tumor consisted of plump neoplastic cells with abundant granular eosinophilic cytoplasm containing acidophilic periodic acid Schiff-positive, diastase-resistant granules. Immunohistochemicalanalysis showed the tumor cells expressed S-100 protein and neuron-specific enolase.Thus, the resected tumor wasdiagnosed as a GCT.Since GCTs are usually benign, endoscopicreleasection an easy and safe treatment. Colonoscopists should consider the possibility of GCT inthe differential diagnosis of submucosal tumors of the colon.