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目前发现血管内皮生长因子(vascularendothelialgrowthfactors,VEGFs)家族包括7个成员VEGF-A,胎盘生长因子(placentagrowthfactor,PlGF),VEGF-B,VEGF-C,VEGF-D,VEGF-E和蛇毒VEGF(snakevenomVEGF,svVEGF);其同源受体有酪氨酸激酶受体VEGFR-1(Flt-1)、VEGFR-2(KDR)、VEGFR-3(Flt-4)等多种类型。其中,VEGF-A与VEGFR-1和VEGFR-2结合在血管生成中起关键作用,而VEGF-C、VEGF-D与VEGFR-2、VEGFR-3结合在淋巴管生成中起关键作用。胃癌血管生成、淋巴管生成对胃癌的发生发展及转移至关重要。近年研究表明,VEGF-A在胃癌组织中高表达,并在胃癌血管生成中起关键作用;VEGF-C、VEGF-D在胃癌组织中高表达,而在胃癌淋巴管生成中起关键作用;VEGF-A、VEGF-C及VEGF-D与胃癌血管转移、淋巴管转移呈正相关。因此,研究VEGFs家族成员在胃癌生长及侵袭转移中的作用及其机制,可为胃癌的抗血管、抗淋巴管治疗提供新的靶点。
It has been found that the vascular endothelial growth factor (VEGFs) family includes seven members, VEGF-A, placenta growth factor (PlGF), VEGF-B, VEGF-C, VEGF-D, VEGF-E and snake venom VEGF, svVEGF). Its cognate receptors are tyrosine kinase receptors such as Flt-1, VEGFR-2 and Flt-4. Among them, the binding of VEGF-A to VEGFR-1 and VEGFR-2 plays a key role in angiogenesis, whereas the binding of VEGF-C, VEGF-D to VEGFR-2 and VEGFR-3 plays a key role in lymphangiogenesis. Gastric cancer angiogenesis, lymphangiogenesis on the occurrence and development of gastric cancer and metastasis is essential. Recent studies have shown that VEGF-A is highly expressed in gastric cancer tissues and plays a key role in angiogenesis of gastric cancer. VEGF-C and VEGF-D are highly expressed in gastric cancer tissue and play a key role in lymphangiogenesis of gastric cancer. VEGF-A , VEGF-C and VEGF-D and gastric cancer vascular metastasis, lymphatic metastasis was positively correlated. Therefore, to study the role of VEGFs family members in gastric cancer growth and invasion and metastasis and its mechanism may provide a new target for the anti-vascular and anti-lymphatic therapy of gastric cancer.