论文部分内容阅读
目的:探讨肾炎康复片辅助标准激素治疗气阴两虚型肾病综合征(NS)的临床疗效以及对血小板数量(PLT)和血浆垂体腺苷酸环化酶激活肽(PACAP)的影响。方法:152例NS患者参照随机按分层随机法分为治疗组80例和对照组72例;两组患者均采取常规支持治疗和对症处理;对照组采用泼尼松,首始剂量l mg·kg-1·d-1,最大剂量不超过60 mg·d-1,连续口服8~12周,再以每2周减少原使用量的10%内服,最后以10 mg·d-1的剂量维持治疗,根据具体情况维持6~12个月,同时给予对症治疗。治疗组在对照组治疗的基础上加服肾炎康复片,5片/次,3次/d,两组均连续治疗12个月。检测治疗前后两组患者的24 h尿蛋白定量,血清白蛋白(ALB),总胆固醇(TC)和甘油三脂(TG)水平;监测两组肝功能,记录治疗过程中不良反应发生率;比较两组治疗前后中医(TCM)单项症状评分;检测两组治疗前后PLT和血浆PACAP水平。结果:治疗组临床总有效率为97.5%,对照组为79.17%,治疗组明显优于对照组(P<0.01);治疗组治疗后24 h尿蛋白定量,TG和TC水平明显低于对照组,血清ALB水平显著高于对照组(P<0.01);治疗后治疗组患者的向心性肥胖和总体不良反应发生率明显少于对照组(P<0.05);治疗组治疗后TCM各单项指标评分均明显低于对照组,比较差异均有统计学意义(P<0.01);治疗组治疗后PLT数量明显低于对照组,血浆PACAP水平显著高于对照组,比较差异均有统计学意义(P<0.01)。结论:肾炎康复片辅助标准激素治疗气阴两虚型NS能提高临床疗效,减少不良反应发生,降低患者血小板数量和升高血浆PACAP水平。
Objective: To investigate the clinical effects of nephritis kang tablet (adjuvant standard hormone) on the treatment of nephrotic syndrome (NS) with deficiency of both qi and yin, as well as the effects on platelet count (PLT) and plasma pituitary adenylate cyclase activating enzyme (PACAP) Methods: A total of 152 patients with NS were randomly divided into treatment group (n = 80) and control group (n = 72). The patients in both groups were treated with conventional supportive therapy and symptomatic treatment. The control group was treated with prednisone, kg-1 · d-1, the maximum dose of not more than 60 mg · d-1, continuous oral administration of 8 to 12 weeks, and then every 2 weeks to reduce the amount of 10% of the original oral administration, and finally 10 mg · d-1 dose Maintenance treatment, according to the specific circumstances to maintain 6 to 12 months, given symptomatic treatment. Treatment group in the control group based on the treatment of nephritis plus rehabilitation tablets, 5 tablets / time, 3 times / d, two groups were treated for 12 months. The levels of 24 h urinary protein, serum albumin (ALB), total cholesterol (TC) and triglyceride (TG) in both groups were measured before and after treatment. The liver function was monitored and the incidence of adverse reactions was recorded. Before and after treatment, TCM symptom scores of TCM were measured; PLT and plasma PACAP levels were measured before and after treatment. Results: The total clinical effective rate was 97.5% in the treatment group and 79.17% in the control group, which was significantly better in the treatment group than in the control group (P <0.01). The urinary protein, TG and TC levels in the treatment group at 24 h were significantly lower than those in the control group (P <0.01). After treatment, the incidence of central obesity and adverse reactions in the treatment group was significantly less than that in the control group (P <0.05). After treatment, the score of each TCM index (P <0.01). After treatment, the number of PLT in the treatment group was significantly lower than that in the control group, and the plasma PACAP level was significantly higher than that in the control group (P <0.01, P <0.01), and the difference was statistically significant (P <0.01). Conclusion: The nephritis rehabilitation tablets assisted standard hormone treatment of Qi and Yin Deficiency type NS can improve clinical efficacy, reduce adverse reactions, reduce the number of patients with platelet and increase the level of plasma PACAP.