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目的:探讨运动相关蛋白-1(MRP1/CD9)在胃癌组织中的表达与胃癌生物学行为之间的相关性。方法:采用组织芯片技术及免疫组化方法对223例胃癌组织的MRP1/CD9蛋白表达进行研究。结果:在胃癌组织中MRP1/CD9表达的阳性率为58.3%,其表达与患者的性别、年龄、浸润深度、胃癌分期无关,而与肿瘤的分化程度、淋巴结转移密切相关。其中高-中分化组表达高于低分化组,差异有显著性(P<0.05);无淋巴结转移组表达高于淋巴结转移组,亦具有显著性(P<0.01)。二元Logistic回归前进法显示:淋巴结转移最先进入方程,是影响MRP1/CD9表达最显著的因素,其次是分化。结论:胃癌组织中MRP1/CD9表达改变与肿瘤的分化、淋巴结转移密切相关。
Objective: To investigate the correlation between the expression of MRP1 / CD9 in gastric cancer and the biological behavior of gastric cancer. Methods: Tissue microarray and immunohistochemistry were used to study the expression of MRP1 / CD9 in 223 cases of gastric cancer. Results: The positive rate of MRP1 / CD9 expression in gastric cancer was 58.3%. The expression of MRP1 / CD9 was not related to the gender, age, depth of invasion and gastric cancer staging, but closely correlated with the degree of differentiation and lymph node metastasis. (P <0.05). The expression in high-moderately differentiated group was higher than that in poorly differentiated group (P <0.05). The expression in lymph node metastasis group was higher than that in lymph node metastasis group (P <0.01). Binary Logistic regression analysis showed that lymph node metastasis first entered the equation, which was the most significant factor affecting the expression of MRP1 / CD9, followed by differentiation. Conclusion: The change of MRP1 / CD9 expression in gastric cancer is closely related to tumor differentiation and lymph node metastasis.