目的探讨甘精胰岛素与门冬胰岛素对应用口服降糖药血糖不能达标的2型糖尿病(T2DM)患者血糖水平的影响。方法选择血糖控制较差的糖尿病患者60例,随机分为两组:一组以甘精胰岛素治疗;一组以门冬胰岛素三餐前注射,两组均与二甲双胍联用,观察治疗前空腹血糖(FBG)、餐后两小时血糖(2 h BG)、胰岛素用量、二甲双胍用量、低血糖发生率血糖达标时间。结果甘精胰岛素组降糖快速稳定,血糖达标时间短,治疗后FBG、2 h BG更理想,日间血糖波动幅度小,低血糖发生率低,优于门冬胰岛素组(P均<0.05)。结论对血糖控制较差的2型糖尿病患者,睡前应用甘精胰岛素治疗,降糖效果显著,且安全平稳。 Objective To investigate the effects of insulin glargine and insulin aspart on blood glucose levels in type 2 diabetes (T2DM) patients with oral glucose-lowering drugs. Methods Sixty diabetic patients with poor glycemic control were randomly divided into two groups: one group treated with insulin glargine; the other group with insulin aspart as the three meals before injection. Both groups were treated with metformin to observe the fasting blood glucose (FBG), two hours postprandial blood glucose (2 h BG), insulin dosage, metformin dosage, incidence of hypoglycemia, blood glucose compliance time. Results The insulin glargine group had a rapid and stable hypoglycemic effect, short blood glucose compliance time, better FBG 2 h after treatment, less fluctuation of blood glucose during the day, lower incidence of hypoglycemia than insulin aspart (P <0.05) . Conclusion Patients with type 2 diabetes with poor glycemic control should be treated with insulin glargine before going to bed. The hypoglycemic effect is significant and safe and stable.