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随着对乳癌预后生物化学标志的深入研究，诸多有效的乳癌预后标志不断出现，报道较多的是组织蛋白酶D，因其与乳癌、特别是与腋淋巴结阴性（Nˉ）的乳癌复发、转移的关系甚为密切而受到人们的重视。并有望成为Nˉ乳癌患者的一项独立预后标志。
With the in-depth study of prognostic biochemical markers of breast cancer, many effective prognostic markers of breast cancer continue to emerge, and cathepsin D is reported more often because of its recurrence and metastasis of breast cancer, especially with lymph node negative (Nˉ) breast cancer. The relationship has been closely followed by people’s attention. It is expected to be an independent prognostic marker for N-breast cancer patients.