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目的 探讨胃癌组织中ｒａｓｐ２１ 、ｐ５３ 和ＰＣＮＡ 的表达及其相关性。方法 采用免疫组化方法检测５７ 例胃癌组织中ｒａｓｐ２１ 、ｐ５３ 和ＰＣＮＡ 的表达。结果 胃癌组织中ｒａｓｐ２１ 、ｐ５３ 、和ＰＣＮＡ 阳性率分别为５４－４ ％ 、５７－８ ％ 和６４－８ ％ 。ｒａｓｐ２１ 的表达与胃癌的病理类型有关，高分化腺癌阳性率最高；ｐ５３ 和ＰＣＮＡ 的表达与胃癌的病理类型无关。结论 胃癌组织中ｒａｓｐ２１和ｐ５３ 的表达与ＰＣＮＡ 的表达呈协同性。
Objective To investigate the expression of rasp21, p53 and PCNA in gastric cancer and their correlation. Methods The expression of rasp21, p53 and PCNA in 57 cases of gastric cancer was detected by immunohistochemistry. Results The positive rates of rasp21, p53 and PCNA in gastric cancer were 54-4 %, 57-8 % and 64-8 %, respectively. The expression of rasp21 is related to the pathological type of gastric cancer. The positive rate of well-differentiated adenocarcinoma is the highest; the expression of p53 and PC-NA has nothing to do with the pathological type of gastric cancer. Conclusion The expression of rasp21 and p53 in gastric carcinoma is synergistic with the expression of PCNA.