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目的探讨甲氨蝶呤联合米非司酮治疗输卵管妊娠的临床疗效及安全性。方法将68例输卵管妊娠患者根据治疗适应证和家属意见分为两组各34例,治疗组患者接受甲氨蝶呤联合米非司酮治疗,对照组患者仅给予甲氨蝶呤。观察两组的临床疗效。结果与对照组比较,治疗组血β-hCG转阴时间、阴道流血停止时间以及超声包块缩小50%时间明显减少(P<0.05);治疗组胃肠道不适发生率显著小于对照组(P<0.05)。结论甲氨蝶呤联合米非司酮治疗输卵管妊娠,其方法简便,疗效高,疗程短,副反应小,且可保留生育功能,患者易于接受。
Objective To investigate the clinical efficacy and safety of methotrexate combined with mifepristone in the treatment of tubal pregnancy. Methods Sixty-eight patients with tubal pregnancy were divided into two groups according to indications of treatment and family members. 34 patients in the treatment group received methotrexate combined with mifepristone, and only methotrexate was given in the control group. The clinical efficacy of the two groups was observed. Results Compared with the control group, the time of β-hCG negative conversion, the time of vaginal bleeding and the time of 50% reduction of ultrasound mass in the treatment group were significantly decreased (P <0.05). The incidence of gastrointestinal discomfort in the treatment group was significantly lower than that in the control group <0.05). Conclusion Methotrexate combined with mifepristone in the treatment of tubal pregnancy, the method is simple, high efficacy, short course, side effects, and can retain the reproductive function, the patient is easy to accept.