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烤牛肉含有致癌物质苯并芘(B(a)P)和其他多环芳烃,摄入这些物质主要经肠道排泄。应用组织培养的代谢研究已表明,人的结肠可使B(a)P转化为近似于致癌物7,8-二氢-7,8二羟基B(a)P并与大肠细胞的DNA结合;人粪便中的细菌也能将B(a)P的胆汁代谢物水解成二氢化合物、酚和醌类。但是,摄入含特殊化合物如B(a)P的烤牛肉,与人类疾病如结肠癌之间的关系,则尚未弄清。B(a)P对结肠作用的生物测定资料也很局限,对摄入B(a)P后,粪便中排泄量以及代谢物的情况还缺乏了解。作者报告了雄性F 344大鼠摄入~(14)CB(a)P
Grilled beef contains the carcinogens benzopyrene (B (a) P) and other polycyclic aromatic hydrocarbons (PAHs), which are mainly released via the intestine. Metabolic studies using tissue culture have shown that human colon converts B (a) P to approximately the carcinogen 7,8-dihydro-7,8-dihydroxy B (a) P and binds to the DNA of the large intestine; Bacteria in human excrement also hydrolyze the bile metabolite of B (a) P into dihydric compounds, phenols and quinones. However, the relationship between the intake of grilled beef containing special compounds such as B (a) P and human diseases such as colon cancer has not yet been clarified. The bioassay data for B (a) P on colon are also limited, and there is a lack of understanding of excretion and metabolites ingested after B (a) P intake. The authors reported ~ (14) CB (a) P in male F 344 rats