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目的探讨配对血浆滤过吸附(CPFA)治疗对重症胰腺炎患者炎性因子的影响。方法选择医院2014年8月-2016年8月收治的重症胰腺炎患者80例作为研究对象,所有患者按床位单双号分为2组各40例。对照组采用高容量血液滤过(HVHF)进行治疗,观察组在对照组治疗的基础上采用CPFA治疗。观察2组患者治疗前后生命体征以及炎性因子变化情况。结果治疗前2组患者心率(HR)、平均动脉压(MAP)及血氧饱和度(Sp O2)比较差异无统计学意义(P>0.05);治疗后2组HR、MAP以及Sp O2水平均改善,且观察组优于对照组,差异均有统计学意义(P<0.05)。治疗前2组患者炎性因子水平比较差异无统计学意义(P>0.05);治疗后2组白细胞计数(WBC)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)以及白介素-10(IL-10)水平均改善,且观察组患者优于对照组,差异均有统计学意义(P<0.05)。结论 CPFA治疗重症胰腺炎患者可有效提高机体免疫功能,改善患者疾病症状,维持稳定的生命体征,值得临床应用及推广。
Objective To investigate the effect of paired plasma filtration adsorption (CPFA) on inflammatory cytokines in patients with severe pancreatitis. Methods Eighty patients with severe acute pancreatitis admitted from August 2014 to August 2016 in our hospital were selected as the study subjects. All patients were divided into two groups of 40 patients according to single and double beds. The control group was treated with high-volume hemofiltration (HVHF). The observation group was treated with CPFA on the basis of the control group. The changes of vital signs and inflammatory factors in two groups before and after treatment were observed. Results There was no significant difference in heart rate (HR), mean arterial pressure (MAP) and oxygen saturation (Sp O2) between the two groups before treatment (P> 0.05). After treatment, HR, MAP and Sp O2 Improve, and observation group than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the levels of inflammatory cytokines between the two groups before treatment (P> 0.05). The WBC, C-reactive protein (CRP), tumor necrosis factor- (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) were all improved in the observation group and the difference was statistically significant (P <0.05). Conclusion CPFA treatment of patients with severe pancreatitis can effectively improve immune function, improve disease symptoms and maintain stable vital signs, which is worthy of clinical application and promotion.